#gene editing
Oct 2026
Programmable thermoregulation of the nuclease activity of LbCas12a.
CRISPR-Cas12a holds great promise for molecular diagnostics and gene editing due to its sequence-specific DNA recognition and robust trans-cleavage activity, yet precise tuning of its nuclease activity remains challenging. Herein, we report a simple temperature-regulation strategy using cost-effective ssDNA blockers, t...
Shi-Wen Tang, Xin-Yi Liao, Jun-Hong Chen et al.
· Biosensors & bioelectronics · 0 citations