The Missing Antigens of Neuroendocrine Tumors: A Null-Hypothesis Framework for Testing Microbial Control of Spatial Immune Editing
Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly regarded as immunologically “cold,” yet this label does not explain their marked spatial heterogeneity in immune infiltration, antigenpresentation machinery, stromal organization, and malignant-cell state. Intratumoral bacterial si...