Author

Balwinder Singh

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Review Sep 2026

Pharmacological interventions for acute major depression and bipolar depression with mixed features: A systematic review and dose-related network meta-analysis across different age groups.

BACKGROUND Acute mixed bipolar/major depression is relatively frequent, yet quantitative information about its pharmacological management is relatively scant, warranting network meta-analysis (NMA) of comparative efficacy/response/acceptability of pharmacological interventions accounting for dose effects across differe...

M. Fornaro, C. Di Lorenzo, Nicolas A. Nunez et al. · Journal of Affective Disorde... · 0 citations

Open access Aug 2026

SGLT2 inhibitors versus GLP-1 receptor agonists and risk of kidney replacement therapy and healthcare utilization in bipolar disorder with chronic kidney disease: An active-comparator, new-user cohort study

Individuals with bipolar disorder (BD) face elevated rates of chronic kidney disease (CKD) and premature mortality yet remain underrepresented in cardiorenal trials. Although sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have established renoprotective ben...

Balwinder Singh, Feyza Yaylaci, Hossam M. Ali et al. · Journal of Affective Disorde... · 0 citations

Review Open access Sep 2026

Modulation of GABA and Glutamate by Ketamine in Depression: A Systematic Review and Meta-Analysis of Magnetic Resonance Spectroscopy Studies

Rigorous RCTs with standardized protocols, larger sample sizes, uniform dosing, and systematic biomarker investigations are needed to clarify ketamine’s neurochemical mechanism and optimize ketamine’s clinical application in treatment-resistant depression.

Balwinder Singh, Hossam M. Ali, Alessandro Miola et al. · Neuropsychopharmacology · 0 citations

Review Jul 2026

Bipolar Disorder in Older Adults: A Comprehensive Overview of Pharmacotherapy Patterns and Clinical Considerations

Addressing the multifaceted diagnostic and pharmacotherapeutic challenges of OABD through dedicated age-specific clinical trials, comparative effectiveness studies, systematic evaluation of deprescribing strategies, and enhanced clinician awareness will be fundamental to improve outcomes for this understudied and expan...

Bashar Asir, Majd Al-Soleiti, Balwinder Singh · Drugs & Aging · 0 citations