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Author

B. Vilhjálmsson

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Open access Sep 2026

Gender-specific associations between polygenic scores and age-specific risk of psychiatric disorders.

BACKGROUND Polygenic scores (PGS) have been used to quantify genetic liability for psychiatric disorders, but it remains unclear how these scores are associated with age- and gender-specific risk of diagnosis. AIMS To examine associations between disorder-specific PGS and age- and gender-specific risk of psychiatric...

Genona T. Maseras, Dan-Ni Chen, C. Albiñana et al. · 0 citations
Open access Jul 2026

Estimating Within- and Between-Family Polygenic Effects For Psychiatric Disorders Under Non-random Ascertainment

Background: Polygenic scores (PGSs) are increasingly used to investigate the genetic architecture of complex traits. In genetics, family study designs are often used to adjust for confounders such as population structure and shared environment. However, family studies may also be particularly vulnerable to to non-rando...

T. Gholipourshahraki, Ciarrah Barry, O. Plana-Ripoll et al. · 0 citations
Aug 2026

Distinguishing different psychiatric disorders using DDx-PRS

Despite great progress on case–control polygenic prediction, an unmet need remains for a method that genetically distinguishes clinically related disorders (e.g., schizophrenia (SCZ) versus bipolar disorder (BIP) versus major depressive disorder (MDD) versus controls). We introduce differential diagnosis–polygenic risk...

W. Peyrot, G. Panagiotaropoulou, L. O. Olde Loohuis et al. · 0 citations

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