Abstract Background Recent increases in common mental disorder prevalence could partly reflect greater persistence of existing disorders. We examined 3-year persistence for anxiety, mood, and substance use disorders, defined as meeting diagnostic criteria at baseline and again during 3-year follow-up. We compared persi...
A. Gkitakou, M. ten Have, N. M. Batelaan et al.· Psychological Medicine· 0 citations
Background Cognitive impairment and immuno-metabolic dysregulation are commonly observed in depressive and anxiety disorders, but underlying brain processes remain unclear. This study examined relationships between immuno-metabolic markers, working memory performance, and task-related functional brain activation in per...
S. Braak, Laura K. M. Han, C. Vriend et al.· Brain, Behavior, & Immunity...· 0 citations
Background Evidence on the association between age and the long-term course of affective disorders remains mixed. Objective This study examined the 6-year symptom and diagnostic trajectories of depression and anxiety in relation to age, and assessed whether social, lifestyle, somatic and clinical factors explained obse...
F. Triolo, Laura K. M. Han, H. Jeuring et al.· BMJ mental health· 0 citations
BACKGROUND
Elevated inflammatory biomarkers have been consistently associated with a subset of depressive symptoms, particularly atypical and energy-related features, as well as antidepressant treatment resistance. This evidence has supported the definition of an inflammatory subtype of major depressive disorder (ISMDD...
B. Vai, T. Cazzella, C. Monopoli et al.· Brain, behavior, and immunit...· 1 citation
OBJECTIVE
Major depressive disorder (MDD) is biologically heterogeneous and encompasses diverse symptom presentations. The authors used large-scale plasma proteomics to examine proteomic associations with categorical MDD status, continuous depression symptom severity, and DSM-IV-defined melancholic and atypical symptom...
K. Watson, Mariska Bot, I. Kosti et al.· American Journal of Psychiat...· 0 citations
Extrapyramidal symptoms (EPS) have been described as intrinsic to schizophrenia spectrum disorders (SSD), beyond medication-induced effects. Among EPS, parkinsonism is the most prevalent subtype and has been linked to poorer clinical and functional outcomes. We aimed to examine the relationships between parkinsonism an...
Joaquín Galvañ, J. López-Moríñigo, Gonzalo Salazar de Pablo et al.· Schizophrenia Research· 0 citations
BACKGROUND
Remotely captured spoken language could provide objective, regular indicators of depression symptom severity. However, research to date has largely used non-clinical, cross-sectional written language and complex machine learning (ML) approaches with limited interpretability.
METHODS
We used linear mixed-ef...
A. Tokareva, J. Dineley, Z. Firth et al.· Journal of Affective Disorde...· 0 citations
This study provides hierarchical insights into the cross-sectional and longitudinal implications of health, stress, and lifestyle exposures for the plasma metabolome in the Netherlands Study of Depression and Anxiety.
D. Klose, Y. Milaneschi, Laura K. M. Han et al.· EBioMedicine· 0 citations
Despite great progress on case–control polygenic prediction, an unmet need remains for a method that genetically distinguishes clinically related disorders (e.g., schizophrenia (SCZ) versus bipolar disorder (BIP) versus major depressive disorder (MDD) versus controls). We introduce differential diagnosis–polygenic risk...
W. Peyrot, G. Panagiotaropoulou, L. O. Olde Loohuis et al.· Nature Genetics· 0 citations
BACKGROUND
Childhood trauma (CT) is robustly associated with suicide ideation (SI) and attempts (SA) in individuals with depressive and/or anxiety disorders. However, pathways underlying these associations and whether they differ between suicide ideation only (SI + SA-) and suicide ideation with attempt (SI + SA+) rema...
Jasper X. M. Wiebenga, L. Lokhorst, A. Hoogendoorn et al.· Journal of Affective Disorde...· 0 citations
Findings show that the directionality of neurovegetative symptoms indexes genetic heterogeneity within MDD, with metabolic biology as a central axis of differentiation.
A. Harder, Rujia Wang, Jacob Bergstedt et al.· medRxiv· 0 citations
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