Renal cell carcinoma (RCC) is amongst the most immune-infiltrated solid tumours, but only a small subset of patients achieves durable response to immune checkpoint blockade therapy. Efforts to characterize the immune microenvironment and molecular regulators responsible for treatment responses have explored numerous fa...
Jennifer Q. Pfeil, Shirley Hui, Daniel Stueckmann et al.· bioRxiv· 0 citations
F fibrovascular and myeloid reprogramming is establish fibrovascular and myeloid reprogramming as a coordinated resistance program, identify actionable therapeutic targets, and support microenvironment stratification in future ICI-based trials.
N. Van Renne, E. Agostinetto, Andrea Joaquín-García et al.· Cell Reports Medicine· 0 citations
This Primer provides a comprehensive guide to the experimental IMC workflow, covering antibody conjugation and panel design, sample preparation, data acquisition and quality control, and detail the computational analysis pipeline, including image preprocessing, segmentation, feature extraction, and both single-cell and...
Lasse Meyer, S. Haefliger, D. Schulz et al.· Nature Reviews Methods Prime...· 0 citations
FACTMx couples latent patient factors with subobservation clustering and per-patient component proportions, enabling direct interpretation and downstream association analyses, and supports joint structured-simple modelling for interpretable multimodal patient stratification.
Kazimierz Oksza-Orzechowski, Małgorzata Łazȩcka, Ł. Koperski et al.· bioRxiv· 0 citations
It is demonstrated that integrated multimodal tumor profiling can inform personalized maintenance treatment decisions and that chemotherapy reshapes tumor cell diversity.
Francis Jacob, R. Wegmann, Joanna Ficek-Pascual et al.· Nature Communications· 0 citations
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