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Ashwaq K. Aljabri

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#gene editing Sep 2026

Abstract A020: A SMARCA1/SMARCA5 double-knockout-repressed ISWI chromatin-state program marks fusion-enriched pediatric sarcoma models and an ISWI-complex dependency signal in rhabdomyosarcoma

The relationship between DKOdown and multiple chromatin-remodeling family programs supports a model in which coordinated chromatin-remodeler activity may contribute to lineage dysregulation, adaptive plasticity, and ISWI-associated vulnerability in rhabdomyosarcoma and related fusion-enriched sarcoma models.

Ashwaq K. Aljabri · 0 citations

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