Genotoxicity Evaluation of Pharmaceuticals
This chapter provides a comprehensive overview of genomic safety considerations for both small molecules and cell and gene therapies. For small chemical entities, testing is essential to identify a possible genotoxic potential early in drug development. Mutations in somatic and germline cells can lead to cancer or heri...
Myriam Lemmens, Andreas Zeller, Hans-Jörg Martus
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