Author

Andrea Y.N. Tan

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#gene editing Open access Oct 2026

The effects of DNA repair factor-Cas9 fusions on homing gene drive performance

CRISPR-based homing gene drives achieve super-Mendelian inheritance by converting wild-type alleles into drive alleles through homology-directed repair (HDR). However, competing end-joining repair can generate resistance alleles that limit drive spread. Although fusing Cas9 to DNA repair-associated proteins has improve...

Ying Wu, Xue-Jiao Xu, Nan Liang et al. · bioRxiv · 0 citations

Open access Aug 2026

Two-locus CRISPR toxin-antidote gene drive for confined population modification

2-locus TARE drives represent promising tools for effective and strongly confined population modification and are constructed with underdominance characteristics, yielding a higher introduction threshold even when drive performance is ideal.

Ruobing Feng, Andrea Y.N. Tan, Zhuoran Lu et al. · bioRxiv · 1 citation