An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2.
A single uORF in KCNQ2 is identified that is highly repressive of protein translation and it is demonstrated that mutations disabling the uORF start codon enhance synthesis of encoded potassium channels and weaken ribosome engagement at the uORF.
D. Huey, Eduardo Guadarrama, J. DeKeyser et al.
· Proceedings of the National... · 0 citations