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Author

Alain Laederach

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Open access Sep 2026

Large-scale structural analysis of pre-mRNA structure using RADIS

This work has developed RADIS (Reactivity Analysis of Deep and Intergenic RNA Structure), a strategy that yields strand-resolved chemical probing reactivity profiles across entire intron-rich loci by creating tiled arrays of RNAs that comprehensively span long genomic distances.

Claire Fleurisson, Si-Jin Chen, Ryan M. Macdonald et al. · 0 citations
Open access Jul 2026

Scanning transcriptomes for nonlinear, domain-level similarities using hmSEEKR

Long noncoding RNAs (lncRNAs) play roles in gene regulation across kingdoms of life. However, lncRNAs with related functions often lack linear sequence similarity, making it difficult to leverage studies of one lncRNA to inform the understanding of others. We describe a k-mer-based hidden Markov model, hmSEEKR, that en...

Shuang Li, Daniel Sprague, Quinn E Eberhard et al. · 0 citations

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