Author

Ai-Qun Li

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Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq.

An ECCITE-seq framework is described to characterize the transcriptomic consequences of perturbing multiple neuronal key driver genes associated with Alzheimer's disease (AD) in human-induced pluripotent stem cell (hiPSC)-derived neurons and allows for the assessment of the regulatory impact of candidate genes implicat...

Jing-Long Zhang, K. Brennand, Bin Zhang et al. · Methods in molecular biology · 0 citations

Open access Aug 2026

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown.

Xiao-Dong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak et al. · Alzheimer's & Dementia · 0 citations

Open access Jul 2026

CRISPR-engineered deletion of POGZ alters transcription factor binding at promoters of genes involved in synaptic signaling

An allelic series of CRISPR-engineered human induced pluripotent stem cell (hiPSC) clones harboring mono- and bi-allelic POGZ deletions are created and shared molecular consequences suggest key points of convergence that connect gene regulation to neuronal function in the etiology of neurodevelopmental pathologies.

M. Moyses-Oliveira, Yating Liu, Serkan Erdin et al. · HGG advances · 1 citation