CRISPR-Based Epigenome Editing for Precision Medicine: Molecular Mechanisms, Therapeutic Applications, Delivery Challenges, and Future Clinical Translation
Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...