Author

Abhay Kotecha

2 papers indexed here

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Open access Oct 2026

Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K+ channel TASK-2

These findings define a paradigm for intracellular channel regulation and offer a structural blueprint for designing specific inhibitors of TASK-2.

Trevor A. Docter, B. Sorum, Bao-Bin Li et al. · Proceedings of the National... · 0 citations

Open access Sep 2026

Ligand-induced activation of RyR1 in native membranes

Synchronized calcium release through arrays of the ryanodine receptor RyR1, fundamental to skeletal muscle excitation-contraction coupling, is achieved through the mechanical interaction of RyR1s and voltage-sensing receptors DHPR that activate RyR1s in response to action potentials. The calcium release is enhanced thr...

Vasilii Mikirtumov, Sabrina Golusik, Rui-Feng Huo et al. · Nature Communications · 0 citations