Author

Aaron Wacholder

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Open access Sep 2026

Environmental stress and phenotypic tradeoff modulate the adaptive potential of novel coding sequences for de novo gene birth

Novel protein-coding genes can emerge de novo from ancestrally noncoding sequences and promote adaptation to environmental stresses. Previous work proposes that pervasive translation of lowly expressed open reading frames (ORFs) in noncoding regions creates a rich reservoir of “proto-genes,” of which subsequent acquisi...

Lin Chou, N. Coelho, S. Parikh et al. · bioRxiv · 0 citations

Open access Aug 2026

The origin of taxonomically restricted genes in yeast

It is demonstrated that most species-specific TRGs are genuine de novo gene births whereas most of the TRGs that are conserved across the Saccharomyces genus derive from highly diverged ancestral genes whose homology is no longer detectable using common methods.

Aaron Wacholder, A. Carvunis · bioRxiv · 0 citations