Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive loss of motor neurons, leading to muscle atrophy and fatal respiratory failure. While neuroinflammation is a hallmark of ALS, the temporal and spatial relationship between systemic inflammation and periphera...
E. Martynova, Marat Mukhamedyarov, E. Kabwe et al.· International Journal of Mol...· 0 citations
An analysis of clinical trial data shows that combination approaches that combine cellular therapy with immune checkpoint inhibitors or standard treatments are the most effective, highlighting the need for further research in personalized immunotherapy for melanoma.
Chulpan B. Kharisova, A. Gorodilova, Y. Mayasin et al.· Kazan medical journal· 0 citations
Development of safe-harbor integration and B2M/CIITA-based hypoimmunogenic designs as strategies to reduce engineering-related batch variability and HLA-dependent donor variability support a transition from empirical optimized MSC preparations toward molecularly defined cellular medicines with predefined genotype, expr...
Kristina V. Kitaeva, I. Filin, A. Rizvanov et al.· Cells· 0 citations
This review provides a roadmap for translational decision-making and identifies critical gaps that must be addressed before MSC-based therapies can be integrated into routine neurological practice.
A. I. Ayupova, Angelina S. Sidorova, Ekaterina A. Luzina et al.· Cells· 0 citations
Clinically applicable gene therapy for RTT will likely need to move beyond simple MECP2 replacement and instead rely on precise cell- and dose-dependent regulation of its expression, with an emphasis on non-coding RNA-based and epigenetic mechanisms.
I. Kabdesh, A. Rizvanov, Y. Mukhamedshina· Non-Coding RNA· 0 citations
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