Spatial transcriptomics of primary and metastatic ALK-rearranged NSCLC reveals site-specific adaptations.
INTRODUCTION Genetic alterations and the tumor microenvironment (TME) influence treatment response in anaplastic lymphoma kinase-rearranged non-small cell lung cancer (ALK+ NSCLC). This study maps site-specific TME adaptations and exploratory risk-associated signatures in lymph node metastases (LNT) to investigate meta...