#gene editing
Sep 2026
Characterization of Cellular Alterations in a Novel NAGLU Enzyme-Deficient Cellular Model Generated from U-87MG Cell Line
A glial cell model deficient in the NAGLU enzyme via CRISPR/Cas9 editing system in the U-87MG cell line exhibited typical traits for MPS IIIB, including decreased enzyme activity and mitochondrial mass, as well as increased lysosomal mass, neutral lipids, total glycosaminoglycans, and total reactive oxygen species.
Katherin D. Niño-Traslaviña, Diego A. Súarez, Oscar F. Sánchez et al.
· Neurochemical Research · 0 citations