#gene editing
Aug 2026
Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation.
Analysis of factors regulating collective cell migration of genome-edited MCF10A cell lines carrying hotspot PIK3CA mutations suggest that polarized actomyosin contractility and pulsatile ERK activation must be constrained in the territory of a phase diagram compatible with mechanotransduction of ERK waves across cell-...
A. Dayoub, A. Fokin, S. Leonov et al.
· Journal of Cell Science · 1 citation