CircARHGAP10 inhibits colorectal cancer cell proliferation, migration and invasion by governing the miR-29a-5p/LPP axis and regulating Wnt/β-catenin signaling pathway
Sep 2026· Molecular and Cellular Biochemistry· Vol 481, pp. 5337 - 5353· 0 citations· 28 references
Medicine
TL;DR
It is revealed that circARHGAP10 functions as a tumor suppressor in CRC via two independent regulatory branches downstream of the circARHGAP10/miR-29a-5p cascade, and this newly identified circRNA-centered regulatory network provides a promising novel therapeutic target for CRC intervention.
To define the functional role of hsa_circ_0054391 (circ54391) in CRC progression and to evaluate its potential as a serum biomarker. Circ54391 was identified from databases and its expression was validated in CRC tissues, cell lines, and serum from healthy controls (
n
= 34), colorectal polyp patients (
n
= 3...
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