TL;DR
Although no statistically significant genetic associations were identified in the present cohort, the bioinformatics findings suggest that these loci remain biologically relevant within Wnt-related pathways.
The findings suggest no significant association between the HTR2A rs6313 and ASD susceptibility in the Jordanian population, and emphasize the need for larger, multi-marker studies to account for regional genetic diversity.
Lower vitamin D levels and the rare rs1338135647 variant may independently co-occur with ASD in Indonesian children; however, these hypothesis-generating findings require replication and functional validation in larger independent cohorts.
rs4821611 in RAC2 and rs757190 in WNT3 are associated with NSOC and its subtypes in the Han Chinese population, supporting a role for Wnt signaling in cleft pathogenesis andGenotypic analysis confirmed these associations.
This study integrated mRNA expression profiles from five post-mortem brain tissue GEO datasets to identify ASD-associated genes and found that EIF4A1 mRNA expression was significantly elevated in ASD subjects and rescued by treatment with the antipsychotics olanzapine or risperidone.
This study provides suggestive evidence that elevated adenine and proline may be potential risk factors for ASD and suggests possible involvement of the mitochondrial–Hippo–microtubule pathway, and proposes benzo[a]pyrene as a candidate environmental toxicant that may perturb CSF metabolism.
The biological plausibility of LNX2 as a candidate gene for neurodevelopmental disorders is supported, highlighting its preferential association with neuronal projection-cell networks, synaptic vesicle trafficking pathways, and neuron-specific regulatory programs.
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