RNA Structure and Its Function.

The RNA structural code: orchestrating gene expression and enabling precision therapies.

Computational modeling of an RNA-peptide world

It is hypothesize that the RNA world was, actually, an ‘RNA-peptide world’, in which, from the earliest stages of evolution, evolving RNA molecules interacted with short random peptides synthesized in a non-templated manner, which could drive the evolution of diverse RNA structures and activities, and eventually, of th...

RNA engineering approaches to aid high-resolution structure determination of medium- to large-sized RNAs.

High-resolution structure determination of RNA remains a major challenge due to its conformational flexibility, intrinsic heterogeneity, and susceptibility to degradation. Although RNA plays central roles in gene regulation, viral replication, and cellular homeostasis, RNA-only structures represent a small fraction of...

In silico designing of small molecules for targeting RNA: current landscape and future directions

The field’s persistent constraints, including lack of structural data, underdeveloped force fields, unresolved selectivity, and the gap between in silico and cellular activity, are examined, and the advances likely to narrow them are examined.

Characterization of RNA Structure Dynamics with Trans-Factors Using Single-Molecule Optical Tweezers.

From RNA design to delivery: Computational strategies for functional RNA therapeutics

RNA therapeutics provide a revolutionary means of treating a variety of diseases by precisely regulating gene expression and protein synthesis, with great medical significance. However, there are three key challenges to its clinical application: the inherent instability of RNA, the need for controlled regulation of RNA...