Quercetin induces molecular hallmarks of immunogenic cell death and cGAS-STING pathway activation via mitochondrial DNA release in hepatocellular carcinoma cells.
Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 1 citation· 39 references
Medicine
TL;DR
It is suggested that QUR concurrently elicits molecular hallmarks of ICD and activates the cGAS‑STING pathway through mtDNA release in HCC cells, which provides a preliminary mechanistic basis for exploring QUR as an immunomodulatory agent for HCC.
It is demonstrated that carvacrol effectively inhibits CRC growth while exerting limited effects on normal colon fibroblasts, which support the further investigation of carvacrol as a potential complementary therapeutic agent for CRC.
A. Abuaisha, H. Arslan, Emir Nekay et al.· Molecular and Cellular Bioch...· 0 citations
The findings identify medicarpin as a novel EGFR‑modulating natural compound that induces Fas-mediated apoptosis in liver cancer, independent of p53 status.
Yong-zhuo Li, Chun-Ping Huang, Jing Li et al.· Phytomedicine· 0 citations
A novel TLR4/NLRP3/Caspase-1/GSDMD axis is elucidated as the core mechanism behind the antitumor effect of OHSV2 and a rationale for its combination with immunomodulators to improve outcomes in bladder cancer is proposed.
Jin-Zhou Xu, Yifan Xiong, Chen-Qian Liu et al.· Molecular Biomedicine· 0 citations
The TQ + DTX combination demonstrated synergistic cytotoxicity and significantly increased apoptotic cell death compared with either monotherapy, providing evidence supporting further preclinical investigation of the TQ + DTX combination as a promising therapeutic strategy for triple-negative breast cancer.
Aylin Orhaner, M. Tuncer, İ. Özdemir· Pharmaceuticals· 0 citations
It is demonstrated that 8-gingerol induces coordinated apoptotic and ferroptotic cell death through a Ca2+-dependent ER stress mechanism, highlighting its potential as a novel therapeutic strategy for the treatment of ovarian cancer.
Tae Woo Kim· Cell communication and signa...· 0 citations
Initial evidence is provided that marbofloxacin induces metabolic and molecular rewiring in BC, highlighting its promise as a repositionable therapeutic candidate.
M. Yavuz, F. R. P. Dewi, Ilknur Keskin et al.· Pharmaceuticals· 0 citations
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