Aug 2026· Neurochemical Research· Vol 51· 0 citations· 46 references
Medicine
TL;DR
Findings demonstrated striatal D2R played a critical role in NEP-induced arousal, and pharmacological blockade of D2R blockade effectively reversed NEP-induced c-Fos expression in the striatum.
Dysregulation of the noradrenergic system has been implicated in the pathophysiology of schizophrenia. Although α2-adenergic receptor (α2-AR) agonists may alleviate positive symptoms, their effects on cognitive and negative symptoms remain controversial. This study aimed to characterize the dose-dependent effects of re...
G. Horvath, S. Plesz, E. Ducza et al.· Neuropharmacology· 0 citations
The serotonin 2A receptor (5-HT2A) is a Gq/11-coupled receptor implicated in reward processing, neuropsychiatric disorders, and the actions of serotonergic psychedelics. Although 5-HT2A activation has been shown to engage endocannabinoid (eCB) signaling in several brain regions, its role in inhibitory synaptic plastici...
Camila Estay-Olmos, Koyam Morales-Weil, Juan Ahumada et al.· Frontiers in Pharmacology· 0 citations
It is indicated that stereochemical and subunit-selective modulation of GABAA receptors critically determines circuit-level outcomes following stress and reinforce α5-GABAA receptors as a key target for normalizing hippocampal-driven dopamine system dysfunction associated with psychosis-relevant states.
Kayla Lilly, Prithu Mondal, James M. Cook et al.· Psychopharmacology· 1 citation
BACKGROUND AND PURPOSE
Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post-cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like p...
C. Edvardsson, Thaynnam A. Emous, S. Witley et al.· British Journal of Pharmacol...· 0 citations
1. Evodiamine has been reported to exert antidepressant-like activity, but the underlying mechanisms remain incompletely understood. This study investigated the antidepressant-like effects of evodiamine and explored its regulation of monoamine neurotransmitter reuptake through modulation of uptake-2 transporters.2. A c...
Xian-Mei Song, Rui-Feng Liang, Yan-Yan Zhang et al.· Xenobiotica; the fate of for...· 0 citations
Preliminary findings suggest that the in vitro stress protocol induces structural and synaptic alterations, and that ketamine rapidly affects expression of several proteins involved in synaptic plasticity.
N. Nicosia, J. Mingardi, G. Terribile et al.· International Journal of Neu...· 0 citations
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