Exercise for the mitigation of cancer therapy-related cardiac dysfunction in breast cancer patients treated with anthracyclines: a systematic review and meta-analysis
Sep 2026· Supportive Care in Cancer· Vol 34· 0 citations· 41 references
Medicine
TL;DR
The cardioprotective role of exercise during anthracycline treatment remains uncertain, though the attenuation of cardiac troponin I elevation suggests a potential protective signal warranting further investigation through larger, standardized trials employing advanced assessment modalities and longer follow-up periods.
Anthracycline-induced cardiac dysfunction (AICD) is cardiac injury associated with potentially cardiotoxic anthracycline therapy, and remains a significant complication for breast cancer patients. Neurohormonal modulation, a therapeutic strategy used primarily in heart failure, including renin–angiotensin system...
R. B. Sidabukke, N. P. Simangunsong, L. A. A. Hadid· European Heart Journal, Supp...· 0 citations
Its use facilitates early detection of subclinical dysfunction and, in selected settings, may improve preservation of left ventricular function; however, a long-term benefit has not been established.
S. Madaliyev, E. Seidalieva, A. Abdrakhmanova et al.· Eurasian Journal of Oncology...· 0 citations
Biomarker- and imaging-guided cardioprotective strategies were seen to be implementable and clinically beneficial for the early detection of anthracycline-associated early cardiotoxicity and substantially reduce the risk of CTRCD.
Lamiya Pirzada, Muhammad Hassan Saeed, Humayou Ahmed· Journal of Saidu Medical Col...· 0 citations
Background: Cancer-therapy-related cardiac dysfunction (CTRCD) remains an important complication of human epidermal growth factor receptor 2 (HER2)-targeted therapy in patients with breast cancer. Although conventional cardiovascular risk factors and serial cardiac imaging are routinely incorporated into cardio-oncolog...
A. Sonaglioni, E. Fossile, M. A. Pessi et al.· Journal of Clinical Medicine· 0 citations
Anthracyclines remain a cornerstone of breast cancer therapy but carry a significant risk of cancer therapy-related cardiac dysfunction (CTRCD). This study evaluates the incidence of CTRCD in an Indonesian setting using the latest 2022 ESC Cardio-Oncology guidelines, focusing on subclinical markers such as high-s...