TL;DR
While the low frequency rebound activity hinders relay of excitatory cortical inputs by the TCR neuron, high frequency stimulation with parameter settings corresponding to this specific window restores the relay functionality.
Improved movement initiation and increased impulsivity under stimulation of the subthalamic nucleus are linked to a shared anatomical and functional substrate, namely the subthalamic nucleus-supplementary motor cortex loop supporting automatic response inhibition.
The stimulation-induced decreases in phase-amplitude coupling were correlated with real-time improvement in bradykinesia and predicted by clinical factors, and could be predicted in task-specific pathways consisting of the primary motor cortex and the dorsal premotor cortex.
The findings suggest that quasi-evoked inhibition is a potential biomarker of tremor reduction by means of network inhibition, and the more posterior regions of the Vim may allow for better recruitment of inhibition, which may be useful for closed-loop stimulation design.
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been explored to treat gait disturbances. However, clinical outcomes of MLR-DBS have been disappointing overall, with only modest benefits in some individuals and unwanted effects, including anxiety, reported in others. Preclinical studies in...
Findings show persistence across the tested dose, GPi→TC, and three-parameter local domains but do not establish evoked relay fidelity, global parameter robustness, biological mechanisms, or clinical efficacy.
Theta-frequency STN-DBS selectively improves visual attention in PD with pre-existing attentional deficits, likely by enhancing top-down attentional resource allocation, while high-frequency stimulation impairs performance.
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