It is argued that while epitranscriptomics represents a compelling regulatory axis in cancer cell death, advancing the field will require integrative, high-resolution, and functionally precise approaches to move beyond correlative frameworks toward mechanistic and clinically actionable insights.
This review critically synthesizes the multifaceted roles of RNA modifications to bridge the gap between descriptive epitranscriptomic mapping and functional tumor biology, and aims to facilitate the translation of epitranscriptomic findings into clinical applications.
Preclinical studies demonstrate that pharmacological inhibition of key regulators, such as METTL3 inhibitors (STC-15, STM2457, UZH2) or FTO inhibitors, can sensitize tumors to platinum drugs and stimulate anti-tumor immunity.
P. Harvanik, T. Hudáková, M. Šemeláková et al.· Advances in Medical Sciences· 1 citation
Clinical translation remains limited by insufficient specificity, tumor heterogeneity, complex crosstalk among RNA modifications, potential toxicity, and delivery barriers, so future studies integrating RNA modification mapping with single-cell, spatial, and multi-omics technologies will be essential to define cell-typ...
Yan-Ni Ma, Wen-Zhi Deng, Xiu-Lin Jiang et al.· Frontiers in Immunology· 0 citations
This review systematically summarize the functional roles of m6A regulators, including writers, erasers, and readers, in breast cancer biology and highlights the emerging clinical potential of m6A regulators as diagnostic and prognostic biomarkers, as well as therapeutic targets for overcoming drug resistance.
Zilong Chen, Chi Zhou, Zhuo-Run Song et al.· Cancer Treatment and Researc...· 0 citations
A model in which mRNA modifications act combinatorially to regulate mRNA homeostasis in plants is supported, including advances in profiling technologies, single-base resolution methods, and nanopore direct RNA sequencing.
Thi Tuyet Suong Ha, S. Park, Dong-Hoon Jeong· Journal of Plant Biology· 0 citations
The molecular mechanisms by which m6A regulates both coding and noncoding RNAs in HCC are summarized, the functional roles of key m6A regulators in hepatocarcinogenesis are highlighted, and the therapeutic potential of targeting the m6A machinery in HCC is discussed.
Xinning Luo, Cuiying Qin, Yi Feng et al.· Discover Oncology· 0 citations
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