Study of Unconventional Cytoskeleton Components Regulating Actin Contraction.

Method for Analyzing Nucleoskeletal Components from the Isolated Nucleus.

Mechanical self-organization of the actin cytoskeleton in artificial cells

The actin cytoskeleton generates diverse cellular functions, including intracellular positioning, symmetry breaking, and cell migration, through dynamic self-organization. Despite extensive molecular characterization of actin-binding proteins, the physical principles by which local molecular interactions give rise to c...

Distinct mechanical regulation of PFK1 isoforms during cytoskeletal remodeling

All cells experience mechanical forces that shape their behavior and organization. These forces are sensed at cell-cell adhesions and transduced through the actin cytoskeleton, triggering cytoskeletal reinforcement to withstand mechanical load. Such remodeling is energy intensive and supported by increased glycolysis,...

Mitochondrial dynamics and mechanosignalling - Integrating metabolic demand and life-death decisions with microenvironmental mechanics.

The way by which cells sense and interpret their microenvironment is fundamental to the regulation of their behaviour. Mechanosignalling is an essential aspect of microenvironmental sensing by cells, particularly within complex three-dimensional tissues, but it remains unclear how this signalling interacts with and mod...

The MICAL family at the Rho-Rab interface: coordinating actin dynamics through oxidation and scaffolding.

The actin cytoskeleton is a complex network of proteins that is constantly being remodelled and reorganized to orchestrate numerous essential cellular processes. From the regulation of proliferation, motility, cytokinesis through to signal transduction, and beyond, the dynamic nature of the actin cytoskeleton is vital...

Dynamic protrusions mediate crawling motility in Asgard archaea.

Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2. Asgard archaea, which are considered the closest known prokaryotic relatives of eukaryotes, potentially encode these functions within their large set of 'euka...