Aug 2026· Cancer Gene Therapy· 0 citations· 22 references
Medicine
TL;DR
Mechanistic investigations demonstrated that NAT10 elevates MARK2 expression, activating the mTOR/HIF-1α/C-Myc signaling cascade, thereby promoting aerobic glycolysis in PCa cells, suggesting that targeting ac4C mRNA modifications may provide a novel therapeutic strategy for managing prostate cancer.
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and the upstream regulatory mechanisms driving oncogenic signaling remain insufficiently defined. In this study, we identify a previously unrecognized nuclear function of the cytoskeletal protein ACTB in promoting ESCC prog...
Yun-Shan Jiang, Dan Zhao, D. Liao et al.· Oncogene· 0 citations
ABSTRACT Hepatocellular carcinoma (HCC) remains a global health challenge due to its high metastatic potential and poor prognosis. This study investigated the role and underlying molecular mechanisms of N-acetyltransferase 10 (NAT10)-mediated α-tubulin acetylation in HCC progression. Using Huh-7 and SNU-449 cell lines,...
It is demonstrated that PSMD11 was markedly upregulated in HCC tissues and correlated with poor patient prognosis, and a PSMD11–PSMD14–SREBP1/2-PPAR-γ–CPT1A regulatory axis that orchestrates metabolic reprogramming in HCC is uncovered.
Zhi-Hong Huang, Can-Xue Zhang, Chi Zhang et al.· Cell Death & Disease· 0 citations
A METTL3-m^6A-IGF2BP2 axis maintains MTFR1 expression to drive glycolytic reprogramming and CRC progression, and represents a prognostic biomarker and a potential therapeutic node linking epitranscriptomic regulation to metabolic adaptation in CRC.
Li-Qiang Wei, Deng-He Liu, Chun-Yu Lin et al.· Journal of Gastroenterology...· 0 citations
BACKGROUND
Metabolic reprogramming, particularly enhanced aerobic glycolysis, is a hallmark of colorectal cancer (CRC) progression and metastasis. However, the key regulatory mechanisms linking glycolytic remodeling to metastatic progression remain incompletely understood.
METHODS
We integrated single-cell RNA sequen...
Hao-Ran Zhang, Jin-Lin Nie, Na Li et al.· International Immunopharmaco...· 0 citations
Findings indicate that the c-Myc-CASC19/HDAC1-NPM1 axis acts as a potential prognostic biomarker candidate for GC and may represent a therapeutic vulnerability worthy of future investigation.
