We present a reusable dataset of neuronal population activity from multiple cortical areas, recorded from layers 2/3 of the mouse cortex at single-cell resolution during wakefulness, natural sleep (including NREM and REM sleep), and isoflurane anesthesia. Using wide-field two-photon microscopy, we recorded approximately 4,000 to 10,000 neurons per session at 7.65 Hz and provided the spatial coordinates of individual neurons. The repository provides both processed datasets and the corresponding raw imaging movies (TIFF) and electrophysiological recordings (MATLAB format). Processed data are distributed in MATLAB format and include Δ F/F fluorescence signals, deconvolved spike estimates, Gaussian-smoothed spike estimates, behavioral state annotations, and metadata. This dataset supports reuse in studies of cortical population dynamics, brain-state-dependent activity, and spatially distributed neuronal organization. It should also be useful for method development, benchmarking, and comparative analyses of large-scale neuronal activity across physiological and pharmacological brain states.
This dataset provides paired single-cell morphology, whole-cell patch-clamp electrophysiology, and source histological slide imagery for juvenile rat neocortical neurons from the EPFL Laboratory of Neural Microcircuitry (LNMC, gathered by MT). The curated explorer subset spans 396 slices, with 244 3D morphological reco...
Maria Toledo-Rodriguez, Ying Shi, Julie Meystre et al.· Frontiers in Neuroscience· 0 citations
In vivo calcium imaging is a powerful technique for the monitoring activity of large neuronal populations in the intact brain. Two-photon microscopy provides subcellular resolution in head-fixed animals, and miniaturized fluorescence microscopy (miniscope) enables recordings of neuronal network activity in freely behav...
Evgenii Gerasimov, Evgenii Fedorov, Ilya Bezprozvanny et al.· Frontiers in Aging Neuroscie...· 0 citations
Understanding how neuronal populations interact to encode and transform sensory information is a fundamental challenge in computational neuroscience. Most existing studies, however, study neural encoding, behavioral readout, and functional connectivity as disjoint problems. Two-photon calcium imaging enables simultaneo...
Sahar Khosravi, Nikolas A. Francis, P. Kanold et al.· PLoS Computational Biology· 0 citations
Membrane potential (or voltage) imaging in acute brain slices is widely used in fundamental and applied neuroscience even in an age characterised by the surge of in-vivo recording. This optical method remarkably increased its ability in providing key information both at the level of single cell and at the level of popu...
Fatima Abbas, Marco Canepari· Neuroscience· 0 citations
Our eyes move constantly. Where they land is shaped by internal cognitive state, making eye movements a rare, non-invasive window onto that state. However, how moment-to-moment eye-movements map onto human neural population activity during naturalistic viewing remains poorly characterized. We analyzed a public intracra...
Carlo Cerquetella, S. Qasim· bioRxiv· 0 citations
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