Genetic Evolution and Molecular Characterization of PRRSV GP5 in Germany

Abstract

Simple Summary Porcine reproductive and respiratory virus (PRRSV) causes significant economic losses in the German swine industry. Yet data on its main structural protein, GP5, have not been systematically analyzed in Germany. GP5 is a glycosylated envelope protein, which plays an important role in immune evasion. In the present study, the evolutionary and structural characteristics of the GP5 gene were analyzed to predict potential evolutionary patterns of PRRSV. The analysis provides molecular insights into prevention strategies and vaccine development. Additional studies on whole genome analysis and spatial structure analysis are needed to deepen the understanding of German PRRSV evolution and the structure of GP5, which can facilitate vaccine development and lay the foundation for prevention strategies.