TL;DR
It is suggested that RST-loaded chitosan nanoparticles represent a promising oral nanocarrier system with sustained release characteristics and the potential to improve the oral performance of poorly water-soluble drugs such as rosuvastatin calcium.
Chitosan-based Pitavastatin nanoparticles successfully enhanced drug solubility and provided sustained release, leading to improved ex-vivo permeability and greater in-vivo anti-hyperlipidemic activity in albino rats.
The present study aimed to develop and evaluate Anastrozole-loaded mucoadhesive microspheres for sustained oral drug delivery using Sodium CMC, Chitosan, and HPMC K4M polymers. Microspheres were prepared by the solvent evaporation method and characterized for their micromeritic properties, percentage yield, drug entrap...
Findings establish chitosan-coated, cholesterol-Tween niosomes as versatile, biocompatible carriers that provide sustained release and preserve bioactivity, with promising potential for ocular drug delivery and broader biomedical applications.
The obtained results confirmed the successful development of LTZ-loaded polymeric nanoparticles with suitable physicochemical properties, efficient drug encapsulation, and sustained release behavior and preserved the cytotoxic activity of LTZ, indicating their potential as an effective drug delivery system.
Objective: The present study aimed to formulate and evaluate a diosmin-loaded niosomal gel for enhanced topical anti-inflammatory activity. Methods: Diosmin, a natural flavonoid with poor solubility and limited bioavailability, was encapsulated into non-ionic surfactant-based niosomes using the thin-film hydration meth...
Apremilast-loaded nanosponges demonstrated sustained drug release, excellent stability, and favorable physicochemical characteristics, indicating their potential as an effective topical delivery system for wound management.
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