Multi-class UHPLC-MS/MS method for the simultaneous determination of 32 endocrine-disrupting chemicals in the urine of pregnant women.

Target quantification and ion mobility-HRMS suspect screening of BPA and its alternatives in human urine.

A fast analytical approach based on ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and ion mobility-high-resolution mass spectrometry (IM-HRMS) was developed for the determination and suspect screening identification of bisphenols in human urine, providing a comprehensive strategy f...

Development and Validation of a UHPLC–MS/MS Method for Trace-Level Determination of N-Nitroso Chlordiazepoxide in Chlordiazepoxide Hydrochloride Capsule Dosage Form

One-step SPE-UHPLC-MS/MS for simultaneous detection of fenbendazole and metabolites in animal-derived foods.

Fenbendazole (FBZ) is a highly effective antiparasitic agent widely used in veterinary medicine; however, its improper application can lead to residues in edible animal-derived products, posing potential health risks to humans through accumulation via the food chain. This study aimed to establish an ultra-high-performa...

Biomonitoring: a demonstration of the importance of direct analytical methods for the assessment of chemical exposures

Introduction Biomonitoring of commercial endocrine-disrupting chemicals (EDCs) increasingly underpins exposure assessment and risk evaluation, yet most large-scale studies still rely on indirect, enzymatic hydrolysis–based methods whose quantitative performance has not been systematically verified. Here, we describe th...

Assessment of Environmental Phenolic Endocrine-Disrupting Chemicals in Human Urine and Their Association with Demographic, Lifestyle, and Metabolic Factors in a Bangladeshi Population Using High-Throughput Solid-Phase Extraction Coupled with UHPLC–Tandem Mass Spectrometry

Background: Environmental phenolic endocrine-disrupting chemicals (EDCs) are widely distributed contaminants associated with plastics, food-packaging materials, thermal papers, flame-retardant products, antimicrobial formulations, and a variety of household and personal-care products. Human exposure to these compounds...

Validation of an integrated analytical method for the simultaneous quantification of 12 PFAS in drinking water, plant-based milk alternatives and skimmed milk.

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants that may threaten food safety. Standardized analytical methods for low-fat liquid foods remain limited. This study validates a novel integrated workflow for the simultaneous determination of 12 PFAS in drinking water, plant-based milk alternatives a...