Enhanced in vitro anticancer activity of a platinum-Mesalazine complex against colorectal cancer cells apoptotic modulation and evidence of non-intercalative DNA binding.

Kimiya Ghasemi Abdolreza Sabokrouh B. Noohi Farrokh Modarresi

Aug 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 28 references

Medicine

TL;DR

Findings indicate that Pt-MES may interact with DNA grooves and facilitate platinum coordination with nucleophilic sites, particularly guanine residues, leading to DNA structural perturbation and activation of apoptotic pathways.

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