Impacts of N-glycanase1 (NGLY1) Down Regulation on the Function of Mitochondria.

Yan-Wen Chen Ruijie Liu Shaoxing Zhang Yuxin Zhang Qiange Lin Yilin Ye Shu-Xing Yuan Xinrong Lu Linfei Wang Li Chen Gui-Qin Sun

Aug 2026 · Journal of Cellular Biochemistry · Vol 127 8, pp. e70119 · 0 citations

Medicine

TL;DR

It is conservatively suggested that NGLY1 has global regulatory roles within cells and the Calnexin/IP3R/VDAC1 axis acts as a communication bridge and represents one mechanism underlying NGLY1-mediated modulation of mitochondrial function.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Open access Oct 2026

Emerging chemical strategies for modulating protein O-GlcNAcylation.

O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) is an essential and dynamic post-translational modification (PTM) that modulates diverse cellular processes. Dysregulation of O-GlcNAcylation is associated with numerous human diseases, yet no O-GlcNAc-targeting therapy has been approved for clinical use, un...

Jia-Jun Wu, Bi-Xuan Ng · Current Opinion in Chemical... · 0 citations

Review Open access Sep 2026

Targeted Control of Protein O-GlcNAcylation in Living Cells.

O-linked N-acetylglucosamine glycosylation (O-GlcNAcylation) regulates many intracellular proteins, but linking a cellular phenotype to O-GlcNAcylation of a specific substrate remains difficult. Global perturbation of O-GlcNAc transferase (OGT) or O-GlcNAcase (OGA) changes many proteins at once and therefore provides l...

Tong-Yang Xu, Billy Wai-Lung Ng · Glycobiology · 0 citations

Open access Oct 2026

Targeting mannosylation of nicastrin N-glycans attenuates γ-secretase activity and notch-dependent leukemia progression

γ-Secretase is a transmembrane protease complex that cleaves multiple type I transmembrane proteins, including amyloid precursor protein and neurogenic locus notch homolog protein (NOTCH). Although numerous γ-secretase inhibitors and modulators targeting Notch-dependent cancers have been developed in recent decades, th...

Hua Jiang, Wei-Xiang Bian, Yan-Jun Cao et al. · Journal of Clinical Investig... · 0 citations

Open access Oct 2026

Effects of Pharmacologically Induced Hyper-Protein O-GlcNAcylation on the Heart Transcriptome

Background/Objectives: O-GlcNAcylation is a post-translational modification affecting diverse cell functions, including transcriptional regulation. Aberrant levels of protein O-GlcNAcylation have been observed in neurodegenerative and cardiovascular diseases. We have previously demonstrated that systemic elevation of p...

Margaret B. Bell, Gloria A. Benavides, Xiao-Sen Ouyang et al. · Journal of Molecular Patholo... · 0 citations

Open access Sep 2026

Mutations in the N-glycan branching enzyme MGAT1 promote invasiveness and EGF-stimulated proliferation and adhesion in neuroblastoma cells

Attachment and modification of N-glycans to proteins have been linked to the promotion of cancer, and specifically, more recent investigations have supported the involvement of less processed N-glycans. Herein, we investigated how reduced activity of N-acetylglucosaminyltransferase-I (GnT-I, MGAT1) influences aberrant...

M. Hall, Lyla J. Walker, Abel R. Messer et al. · PLoS ONE · 0 citations

Open access Oct 2026

Identification of active deubiquitinases in dendritic cells under unstimulated and activated conditions

Ubiquitination is a post-translational modification with well described roles in the regulation of immune cell function, such as dendritic cells (DCs). DCs are crucial initiators and regulators of T cell-mediated immune responses. In this study, we use activity-based probes and proteomics to systematically profile DUBs...

Huw Morgan, J. Villadangos, Laura Edginton-Mitchell et al. · bioRxiv · 0 citations