Proteomics analysis of Pseudomonas plecoglossicida under thermal stress: the Entner-Doudoroff pathway as a temperature-dependent metabolic switch for thermal adaptation
The proteomic basis of thermal adaptation in P. plecoglossicida is revealed and molecular targets for engineering thermotolerant strains to optimize industrial 2-KGA fermentation are provided.
Under severe stress, GO and KEGG enrichment consistently revealed the reinforcement of central carbon and energy metabolism, peroxisome-associated fatty acid turnover, oxidoreductase/redox activities, and translation and nucleotide metabolic pathways.
Dingkang Wang, Li Wang, Yue Xiao et al.· Journal of Proteome Research· 0 citations
This work resolves the fundamental oxygen contradiction between thermotolerance enhancement and product biosynthesis in high-temperature fermentation, providing a transformative strategy for cost-effective and sustainable industrial biomanufacturing.
Zhongmei Hu, Yanjie Li, Na Dong et al.· Bioresource Technology· 0 citations
This study revealed that mutations in key enzymes and transcriptional regulators at various metabolic branching points were essential for effective growth on D-xylose, enabling optimized partitioning of carbon through central metabolism despite the loss of the canonical EMP glycolytic route.
C. Iacometti, Valérie A. Delmas, Mélodie Cadillon et al.· Metabolic Engineering· 0 citations
Temperature constrains stable mycelial growth and production of Oudemansiella raphanipes, but its molecular response to heat stress followed by recovery remains insufficiently resolved. We integrated untargeted LC-MS metabolomics and RNA sequencing to compare control mycelia maintained at 28 °C (HPJZ28) with mycelia ex...
Yangyang Peng, Jianhao Wang, Ling-Jun Xu et al.· Journal of Fungi· 0 citations
Results suggest CgASS as a potential key node of a metabolic compensation–decompensation axis and a molecular target for breeding thermally resilient shellfish.
Haining Wang, Pengcheng Sun, Peng Li et al.· Fishes· 0 citations
This study uncovers a previously unappreciated mechanism of Tps1-mediated heat adaptation in C. deneoformans, by revealing that Tps1 functions as a critical metabolic gatekeeper that safeguards glycolytic flux to sustain growth at elevated temperatures.
V. Yadav, Kahlia A. Carl, J. Heitman et al.· bioRxiv· 0 citations
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