The circadian system is affected by Alzheimer’s disease independently from amyloid beta deposits

Circadian Rhythm Disruption in Alzheimer's Disease: Mechanistic Insights, Diagnostic Implications, and Emerging Chronotherapeutic Strategies: A Narrative Review.

There is a link between circadian rhythm abnormalities and Alzheimer's disease, and non-invasive biomarkers for the early identification of circadian nonalignment may aid in preventative measures.

Circadian Rhythm Disruption in Alzheimer's Disease: Molecular Mechanisms, Clinical Implications, and Therapeutic Approaches.

The molecular interplay between circadian rhythm disruption and AD pathology is critically evaluated, its impact on clinical manifestations and disease progression is explored, and emerging diagnostic and therapeutic strategies to restore circadian regulation and improve patient outcomes are assessed.

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

Circadian rhythm disturbance is highly prevalent in patients with Alzheimer's disease (AD) and is consistently associated with more rapid cognitive decline and reduced quality of life. Accumulating evidence supports a bidirectional relationship between circadian rhythm disruption and AD pathology, in which each may r...

The orexinergic system in Alzheimer's disease: from sleep disruption to accelerated neurodegeneration.

What can narcolepsy teach us about hypocretin and dementia?

Sleep and circadian disturbances are associated with cognitive decline and dementia. Narcolepsy type 1 (NT1), characterized by severe sleep-wake disruption and loss of hypocretin, would therefore be expected to predispose individuals to premature brain aging. Yet available biomarker and neuroimaging findings do not con...

Running out the clock: Circadian rhythm dysfunction in cognitive disease

New avenues of investigation that involve mammalian chronobiology with circadian rhythm clock genes and related pathways of aging, cellular senescence, oxidative stress, metabolic dysfunction, sleep fragmentation, apolipoprotein E, programmed cell death, silent mating type information regulation, nicotinamide adenine d...