TL;DR
This study provides robust genetic evidence that circulating 25(OH)D levels are not a major causal determinant of HNC risk and that the instruments are not confounded by major lifestyle or UV-related factors.
Lower, rather than higher, UA concentrations may be associated with an increased risk of lung cancer, as predicted using the inverse variance weighted (IVW) method and other MR approaches.
Background A growing body of evidence implicates vitamin D deficiency (VDD) in carcinogenesis, yet evidence linking VDD to female genital cancers remains inconsistent, with most studies evaluating individual cancer subtypes in isolation using heterogeneous designs. Methods We conducted a retrospective propensity score-...
Serum 25(OH)D and dietary intake showed no significant pooled associations, whereas VDR FokI was associated with increased gastric cancer susceptibility, whereas the absence of paediatric evidence highlights an important knowledge gap.
Genetic evidence of potential associations between antidepressant use and increased risks of Hashimoto's thyroiditis and hypothyroidism is provided, and support consideration of thyroidfunction monitoring in patients receiving antidepressant treatment, particularly those with pre-existing thyroid risk factors.
An independent observational association between hyperthyroidism and an increased risk of HDP is demonstrated, and supportive genetic evidence for a possible bidirectional association between genetically predicted TSH and HDP is provided.
This MR study ruled out the causal relationship between OCC and lymphoma and identified a statistically significant inverse correlation between mature T/NK-cell lymphoma and OCC.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
