5-hydroxy-1-methylhydantoin (NZ-419), an endogenous antioxidant, attenuates mycotoxin-induced oxidative stress in human kidney proximal tubular epithelial cells

E. Ofori-Attah Mai Hashimoto Mayu Oki Hisao Kansui Hitoshi Maeda Shoko Okazaki Keizo Takeshita D. Kadowaki

Aug 2026 · Clinical and Experimental Nephrology · Vol 30, pp. 1398 - 1414 · 0 citations · 48 references

Medicine

TL;DR

Findings provide mechanistic evidence for the protective effects of NZ-419 and support its potential as a renoprotective agent against oxidative stress-related kidney injury.

DOI PubMed Semantic Scholar

View source

Similar papers

Aug 2026

Antioxidant efficacy of N-acetylcysteine against acrylamide-induced toxicity in Leydig cells by modulating p53/Bax/Caspase-3 pathway.

Acrylamide (Acr) is a widely encountered environmental and dietary toxicant known to induce oxidative stress and disrupt male reproductive function. Leydig cells, due to their high metabolic activity and mitochondrial dependence, are particularly vulnerable to redox imbalance. N-acetylcysteine (Nac), a thiol-containing...

Banu Orta Yilmaz, Iremnur Sarialioglu, Gokce Elmaci et al. · Drug and chemical toxicology... · 0 citations

Open access Jul 2026

Protective Effects of Limonene and a Nano-Liposomal Limonene Formulation Against Chlorfenapyr-Induced Renal Toxicity: Mechanistic Insights into NRF2/HO-1 and NF-κB/COX-2 Signaling, Mitochondrial Dysfunction, and Apoptosis in Rat Kidneys

Overall, nano-liposomal delivery enhanced the renoprotective efficacy of limonene, highlighting its potential as a therapeutic strategy against pesticide-induced kidney injury.

E. Elmorsy, Amina A. Farag, Amal M. Abdel-Kareim et al. · Toxics · 0 citations

Aug 2026

In vitro protective effects of cyanidin-3-O-glucoside against toxicity induced by continuous exposure to antimony(III) in intestinal epithelial cells.

Antimony (Sb), a heavy metal employed in PET manufacturing, is an emerging contaminant due to its ability to leach into food and beverages. Chronic exposure can impair intestinal health by disrupting epithelial barrier functionality and promoting oxidative stress, inflammation, and apoptosis. This study investigated th...

F. L. Salamone, M. S. Molonia, Santi Trischitta et al. · Environmental Toxicology and... · 0 citations

Aug 2026

Morin attenuates vancomycin-induced nephrotoxicity via Nrf-2/HO-1, SIRT1/PGC1α and AKT/FOXO1A pathways

Morin (MOR) treatment significantly ameliorated VCM-induced renal injury by reducing oxidative injury, restoring endogenous defense systems, attenuating inflammatory responses, suppressing apoptosis, and markedly improving histopathological lesions.

S. Tekin, Merve Bolat, Burak Batuhan Laçin et al. · Molecular Biology Reports · 0 citations

Open access Jul 2026

Modulation of Dietary 5-Hydroxymethylfurfural-Induced Intestinal Epithelial Stress by Blueberry Polyphenols

Ultra-processed foods expose consumers to heat-induced contaminants like 5-hydroxymethylfurfural (5-HMF), which impairs intestinal homeostasis via oxidative stress and inflammation. This study quantified 5-HMF in bakery products and evaluated blueberry polyphenols’ capacity to attenuate 5-HMF-induced cellular stress in...

R. Mare, F. Noto, Martina Rago et al. · International Journal of Mol... · 0 citations

Open access Aug 2026

Stanniocalcin-1 Overexpression Protects Porcine Intestinal Epithelial Cells Against TBHP-Induced Oxidative Stress by Preserving Mitochondrial Homeostasis

Stanniocalcin-1 (STC-1) is a multifunctional glycoprotein; however, its role in protecting intestinal epithelial cells against oxidative injury has not been completely elucidated. This study investigated the cytoprotective effects and underlying molecular mechanisms of STC-1 overexpression in porcine intestinal epithel...

Liming Wu, Yan Bin, Yu-Bei Wei et al. · Animals · 0 citations