Aug 2026· Electronics· Vol 15, pp. 3484· 0 citations· 35 references
TL;DR
NERFlow is introduced, a workflow-driven subsystem of the FIT4NER project whose contribution is an abstraction layer that makes rule-based, model-based, and LLM-based annotation interchangeable and comparable within one configurable workflow environment.
Abstract
Preparing training data for domain-specific medical Named Entity Recognition (NER) involves a trade-off between annotation quality, expert effort, and data privacy: manual annotation is costly, whereas cloud-based Large Language Models (LLMs) raise concerns about the control of sensitive clinical text. This article introduces NERFlow, a workflow-driven subsystem of the FIT4NER project whose contribution is an abstraction layer that makes rule-based, model-based, and LLM-based annotation interchangeable and comparable within one configurable workflow environment. Open-source LLMs are integrated as exchangeable annotation services, deployable locally or in cloud-agnostic infrastructures via Kubernetes, and embedded into the KM-EP knowledge management system. NERFlow was evaluated qualitatively, through a cognitive walkthrough, an IEEE 1028 technical review, and a user-centered survey with 18 participants, and quantitatively on the CRAFT corpus with seven open-source and hosted LLMs run through an identical pipeline. The results support its use as LLM-assisted pre-annotation with expert correction, with locally deployable open-source models as the more reliable basis for reproducible operation.
Abstract Background Collaborative Research Centers rely on FAIR-compliant, richly structured metadata, yet manual annotation is a major bottleneck. We implemented a search-augmented large language model (LLM) workflow within a local research data management system to pre-annotate biomedical entities, using human-in-the...
M. Watter, F. Engel, Aref Kalantari et al.· Bioinformatics Advances· 0 citations
SIFTING enables accurate, structured, and traceable information extraction from clinical free-text documents and ensures data control, reproducibility, and verifiable outputs that can support clinical validation and workflow integration.
Mirco Hess, Gerben van Veenendaal, J. Wakkie et al.· 0 citations
Biomedical named entity recognition (NER) and relation extraction (RE) remain challenging because biomedical texts contain ambiguous abbreviations, complex entity boundaries, domain-specific terminology, and implicit relations. This study proposes a prompt-enhanced and QLoRA-adapted large language model framework for b...
It is demonstrated that the effectiveness of LLM-assisted DH depends more on the design of a structured HITL workflow rather than on the LLM alone, and combining preprocessing, iterative verification, and targeted human oversight improved the efficiency and reliability of DH while preserving researcher judgment for com...
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Results demonstrate that InfoFlowEX equips LLMs with robust adaptability, achieving consistent gains over baselines with minimal task-specific customization, highlighting InfoFlowEX for real-world biomedical applications.
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This work demonstrates how validation can serve not only as a quality assurance mechanism, but as a central organizing principle for workflow automation, enabling scalable and reliable content management across a distributed XML ecosystem.
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