Stochastic analysis sharpens rather than erodes the thesis: the ignition boundary acquires a predicted width, and noise punishes the reactive policy that parks the system against it.
Abstract
Large language model providers are compute constrained, and their universal response to congestion is to degrade service: route queries to smaller models, cut reasoning effort, truncate context. The industry's accounting says this saves money. We show the accounting is wrong, because it prices a query when the customer buys an answer. A degraded answer fails with some probability, and a failed answer either returns as a retry, inflating arrivals when the system is most loaded, or departs as churn, destroying lifetime value on a ledger no cost dashboard displays. We model inference allocation with three classical primitives: a newsvendor whose stockout cost is churned lifetime value, a geometric retry multiplier in which the recycled product is dissatisfaction, and a two-regime transient queue whose arrival rate is made endogenous by retries. Statically, there is a nonempty, measurable regime in which a cheaper model saves energy per satisfied answer while consuming strictly more capacity per satisfied answer, so the discount inverts exactly when capacity binds. Dynamically, a reactive throttle fired during a surge can cross an ignition threshold beyond which it manufactures more traffic than it sheds, and a release rule set below the degraded equilibrium converts a transient surge into a permanent degraded regime. With heterogeneous customers, throttling is a transportation problem in retry-inflated load whose optimal policy rations intelligence by critical ratio, class by class, and whose dual, the shadow price of intelligence, prices a marginal query by class and by hour; closed-form trajectories make it computable in milliseconds. Stochastic analysis sharpens rather than erodes the thesis: the ignition boundary acquires a predicted width, and noise punishes the reactive policy that parks the system against it. Under congestion, throttling is not a cost lever but a demand lever.
LifeSciBench is introduced, a benchmark of 750 expert-authored tasks designed to evaluate whether language models can handle realistic life science research work, with each constituent task paired with a human expert-written rubric.
Amelia Liu, Andrew Ho, Anne Marie Droste et al.· bioRxiv· 2 citations
A rapidly advancing precision-therapy pipeline-including antisense oligonucleotides to upregulate the intact allele, AAV-based gene replacement, CRISPR-mediated transcriptional activation, epigenetic modulators, and rational pathway-targeted small molecules-offers realistic prospects for disease modification.
Autistic children experience disproportionately high rates of anxiety, yet common interventions such as cognitive behavioural therapy and traditional mindfulness practices may be less effective due to their cognitive and abstract demands. Yoga nidra, a form of guided meditation using concrete visualisations and breath awareness, may offer a more accessible alternative. This mixed methods study evaluated the feasibility and pilot efficacy of a co-designed six-week online yoga nidra intervention targeting anxiety in autistic children aged 8-14 years. Neurophysiological and psychological data were collected from 13 participants using parent- and self-reported measures of anxiety (ASC-ASD), intolerance of uncertainty (IUSC), and emotion dysregulation (EDI), alongside heart rate variability (HRV). Notably, the cohort included a minimally speaking child, which demonstrates the potential for the intervention to extend to autistic children with language support needs, a group who are often underrepresented in similar research. Results indicated no statistically significant changes in anxiety over time; however, medium effect sizes were observed in self- (Hedge's g = 0.55) and parent-reported anxiety (Hedge's g = 0.45), with three participants moving from clinically significant to non-significant anxiety levels post-intervention. Additionally, intolerance of uncertainty and emotion dysregulation demonstrated small to medium effect size reductions (IUSC, Hedge's g = 0.50; EDI-Reactivity, Hedge's g = 0.55; EDI-Dysphoria, Hedge's g = 0.25), suggesting potential benefits of yoga nidra in these areas. Greater attendance was significantly associated with self-reported reductions in anxiety (ASC-ASD-SR, r = .757, p < .05), but not the other outcome measures. Unexpectedly, HRV outcomes indicated reduced autonomic functioning post-intervention. Additionally, qualitative data from semi-structured interviews with three child participants and their mothers from the study were analysed using reflexive thematic analysis, revealing five key themes of their experience: Thinking About the Body is Hard; We Want More; Homework Sucks; Making Mindfulness Concrete; and On-Screen and At Home is Convenient. While the online format was appreciated for its accessibility, challenges with adherence and scheduling highlighted the need for more flexible delivery models. This study advances upon prior research by being the first to develop a co-designed yoga nidra intervention specifically for autistic children. Findings support the feasibility of yoga nidra as a complementary intervention for autistic children and suggest directions for future research, including larger trials and further co-design with the autistic community.
Tundi Loftus, Shu H Yau, Sophia Soares et al.· Research in Developmental Di...· 1 citation
TestifAI, a deep learning testing framework for efficient and accurate estimation of robustness against combinations of perturbations, is proposed and partial model tomography is introduced, a novel approach to reconstructing model behaviour in a multi-perturbation space from tests that apply only a small number of perturbations.
Arooj Arif, T. Hartung, E. Botoeva et al.· 1 citation
FPGAgent is the first task-specification-to-executable HLS generation framework experimentally validated on a well-established benchmark, and the value of end-to-end validation is demonstrated.
Tianyu Wang, Wenjie Wang, Jianguo Yao et al.· 0 citations
Large Language Models show potential in their diagnostic accuracy and consequent ability to reduce clinician burden, and may provide the greatest benefit when used to optimise referral quality at source, improving both clinician and potentially LLM triage downstream.
K. Surendran, I. Aziz, Glyndwr Jenkins· Current Surgery Reports· 0 citations
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.