Whether the Mini‐Mental State Examination Clinical Dementia Rating Sum of Boxes (MMSE–CDR‐SB) residual, defined as observed minus expected CDR‐SB from a published MMSE–CDR‐SB reference equation, reflects clinically meaningful deviation from the expected cognitive–functional relationship is tested.
Abstract
In clinical practice, patients with Alzheimer's disease (AD) often present with cognitive and functional profiles that diverge from what is expected. We tested whether the Mini‐Mental State Examination Clinical Dementia Rating Sum of Boxes (MMSE–CDR‐SB) residual, defined as observed minus expected CDR‐SB from a published MMSE–CDR‐SB reference equation, reflects clinically meaningful deviation from the expected cognitive–functional relationship.
Episodic memory demonstrated the strongest predictive performance among the individual assessment domains evaluated of 24-month progression from MCI to AD, with functional assessment providing substantial complementary value.
Cognitive impairment is an important non‐motor manifestation of amyotrophic lateral sclerosis (ALS), particularly across the ALS–frontotemporal dementia (ALS–FTD) spectrum. Cerebrospinal fluid (CSF) tau and amyloid biomarkers may reflect nonspecific neurodegenerative injury, concomitant Alzheimer disease (AD) pathology...
Aasim Ali, Muhammad Arif, Usama Ashraf et al.· Brain and Behavior· 0 citations
The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer's disease in older adults, and suggest depression and other neuropsychiatric symptoms may be predictors of AD's progression during its "preclinical" phase.
Socio‐demographic variables, rather than individual non‐motor symptoms, demonstrate the strongest independent associations with diagnostic timing in this cohort, highlighting the need for socio‐demographically tailored screening strategies in the prodromal phase of PD.
Shakawat Hossain, Farjana Islam· Health Science Reports· 0 citations
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