MicroRNA-148a regulates depressive-like behaviors in mice via the Otx2/Dopaminergic signaling axis.
Yi-Jun Tang
Huicong Feng
Yue Li
Lu-Peng Zhang
Chi-Wen Qu
Tianai Zhu
Doudou Zhang
Yi Wen
Xiaomin Zeng
Yong Zhang
Xiao-Ning Peng
Medicine
TL;DR
It is demonstrated that miR-148a critically modulates astrocyte-neuron interactions and dopaminergic homeostasis through the OTX2 axis, contributing to mood and cognitive disturbances.