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Associations between lifestyle, genetic risk for Alzheimer's disease, and longitudinal brain atrophy in the UK Biobank (N = 3265)

Yating You Laura M. Lyall Frederick K. Ho Claire E. Hastie D. M. Lyall

Jul 2026 · Alzheimer's & Dementia · Vol 18 · 0 citations · 47 references

Medicine

TL;DR

This study reinforces the independent effect of APOE ε4 on longitudinal brain atrophy, and provides no evidence this varies by APOE ε4 genotype.

Abstract

The associations of modifiable daily lifestyle variables (e.g., smoking, diet, alcohol intake, sedentary behavior, and physical activity) with structural brain atrophy, and interaction with apolipoprotein E (APOE) ε4 genetic risk, remain unclear.

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