Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis
Jul 2026· Annals of Clinical and Translational Neurology· Vol 13, pp. 2154 - 2160· 0 citations· 15 references
Medicine
TL;DR
PRLs and larger CP reflect cognitive progression independent of clinical/MRI activity, supporting their role as smoldering disease activity markers.
Abstract
Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally. PRLs and CP volume were evaluated at diagnosis using 3 T‐MRI. Cognitive decline over time was classified as cognitive progression independent of relapse/MRI activity (PIRMA). Fifty‐five patients (63.2%) showed meaningful cognitive decline: 44 (80.0%) were cognitive PIRMA. PRLs and CP volume at diagnosis were associated with cognitive PIRMA. PRLs and larger CP reflect cognitive progression independent of clinical/MRI activity, supporting their role as smoldering disease activity markers.
Background and Objectives Paramagnetic rim lesions (PRLs) have been established as a radiologic surrogate for chronic active inflammation in multiple sclerosis (MS). Although associations between PRLs and disability have been observed, data on their prognostic value for long-term risk of clinical worsening, especially...
M. Lauerer, Cuici Voon, Julian McGinnis et al.· Neurology· 0 citations
BACKGROUND
The 2024 McDonald criteria allow multiple sclerosis (MS) diagnosis in pre-symptomatic individuals but their association with MRI activity remains uncertain. We assessed whether paramagnetic rim lesions (PRL) predict future MRI activity beyond the 2024 McDonald criteria.
METHODS
We retrospectively included...
Elena Barbuti, S. Borrelli, F. Guisset et al.· Journal of Neurology Neurosu...· 0 citations
Underlying tissue destruction in Definite vs Probable PRLs in people with progressive MS is assessed using quantitative MRI to assess underlying tissue destruction in PRLs in people with progressive MS.
S. Sacco, Hao-Jun Zhao, Shui-Ting Cheng et al.· Neurology(R) neuroimmunology...· 0 citations
BACKGROUND
Cognitive impairment in multiple sclerosis (MS) is common but only weakly explained by conventional magnetic resonance imaging. Proton magnetic resonance spectroscopy (¹H-MRS) detects microstructural damage in normal-appearing white matter (NAWM). We examined whether regional NAWM metabolic profiles are spat...
Advanced diffusion MRI-derived U-fiber metrics may complement clinical measures for exploratory PIRA risk stratification in RRMS and warrant validation in independent multicenter cohorts.
Yi-Xian Li, Zi-Chun Yan, Zhuo-Wei Shi et al.· Academic Radiology· 0 citations
BACKGROUND
Magnetic resonance imaging (MRI)-derived choroid plexus (CP) volume has been associated with cognition in Parkinson's disease, but its close relationship with ventricular anatomy complicates interpretation.
METHODS
We analyzed Parkinson's Progression Markers Initiative (PPMI) data. Baseline FreeSurfer-deri...
Qian-Kun Lv, Zi-Qiu Zhou, Ling-Ying Shi et al.· Parkinsonism & Related Disor...· 0 citations
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