Aug 2026· Apoptosis· Vol 31· 0 citations· 41 references
Medicine
TL;DR
This study provides the first evidence demonstrating the functional role of Sema4f in cardiac fibroblast activation and fibrosis progression, and identifies a fibroblast-specific mechanism mediated by the Sema4f-actin cytoskeleton-YAP/TAZ axis, offering novel mechanistic insights into fibrosis regulation and revealing a promising therapeutic target for cardiac fibrosis with potential clinical applications.
Cardiac transcriptomic responses in zebrafish at 14 days post-cryoinjury revealed distinct transcriptome clusters corresponding to healthy and injured hearts, highlighting significant changes during cardiac regeneration.
Hong Wang, J. Paavola, S. Perttunen et al.· Basic Research in Cardiology· 0 citations
ERIO is a safe, effective natural flavonoid with promising preclinical efficacy, suggesting its potential clinical translation for myocardial fibrosis and offering new therapeutic targets to prevent heart failure progression.
Yu-Ting Liu, Yan Che, Yazhi Ding et al.· British Journal of Pharmacol...· 0 citations
In vivo injection of a PANX1 blocker provides evidence for the role of Panx1 in alleviating cardiac fibrosis and bioinformatics analysis suggests that this process is associated with the JAK/STAT signaling pathway.
Lieyang Qin, Yunjing Zhang, Diyaerjiang Aierken et al.· Acta Biochimica et Biophysic...· 0 citations
A role for FAP in cardiac fibroblast activation is supported and its induction to altered ER-phagy-related proteostasis and ER stress is linked to altered ER-phagy-related proteostasis and ER stress.
Hong-Ju Huang, Qing-Shan Yang, Zhen-fang Zhou et al.· Biochemical and Biophysical...· 1 citation
A novel role is identified for POU2F1 in hypertensive cardiac fibrosis, demonstrating that it exacerbates disease progression by disrupting mitochondrial homeostasis through transcriptional activation of PINK1, accompanied by alterations consistent with enhanced PINK1/Parkin-mediated mitophagy signaling.
Yong-Bo Ma, Xiao-Zhe Chen, Zi-Xian Liu et al.· Molecular Medicine Reports· 0 citations
It is demonstrated that loss of Smyd5 induces rapid progression to heart failure accompanied by robust inflammatory activation, including a ∼100-fold increase in Il-6 expression, accompanied by rapid progression of cardiac remodeling and heart failure.
R. Bia, Samuel M. Hickenlooper, Mickey R. Miller et al.· bioRxiv· 0 citations
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