The cellular and molecular mechanisms of EndMT relevant to CKD are summarized, key regulatory pathways and pathway crosstalk are highlighted, and emerging pharmacological approaches to limit EndMT, preserve microvascular integrity, and attenuate renal fibrogenesis are discussed.
The pathological signaling pathways governing EndMT in cardiac fibrosis are summarized and the emerging roles of exosomal miRNA-mediated crosstalk in cardiac remodeling are discussed to provide new insights into therapeutic strategies targeting cardiac fibrosis.
Lan Phuong Phan, Kyung-Sun Heo· Korean Journal of Physiology...· 0 citations
Endothelial-to-Mesenchymal Transition (EndMT) is a significant contributor to Blood- Brain Barrier (BBB) dysfunction in various brain diseases. The majority of current therapies, aimed at reducing BBB dysfunction, focus on preventing inflammation or stabilizing tight junctions. In most cases, these therapies do not pro...
Nur Iffah Ishak, R. Siran, Wan Nor I’zzah Wan Mohamad Zain et al.· CNS and Neurological Disorde...· 0 citations
It is shown that SMOC2 localized to the basement membrane of injured TECs across 3 murine models of kidney injury and induced a partial epithelial-to-mesenchymal (EMT) transition in TECs, and its extracellular calcium-binding domain mediated binding to the decellularized extracellular matrix accounted for most of its e...
Clinically, circulating and urinary GDF15 levels correlate with disease severity and independently predict renal function decline, suggesting utility in both early diagnosis and prognostic stratification and its potential role as a pharmacodynamic marker responsive to interventions such as metformin and SGLT2 inhibitor...
Yu Chen, Min Li, Min Yang et al.· Journal of Medical Biochemis...· 0 citations
This review examines emerging mechanisms that govern kidney fibrogenesis, with emphasis on therapeutic tractability, and considers how experimental models can improve target prioritization and drug development, and summarizes repurposed drugs, pathway-targeted agents, receptor-directed strategies and cell-based approac...
It is shown that MGP deficiency attenuates renal fibrosis, suppresses fibroblast activation, and preserves kidney function following folic acid nephropathy and unilateral ureteral obstruction, supporting MGP as a potential fibroblast-associated target for future strategies aimed at limiting CKD progression.
Jonatan Barrera-Chimal, J. López-Ramirez, Nathalie Henley et al.· Molecular Biomedicine· 0 citations
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