Biodegradable Polylactic Acid/tea Polyphenols Scaffolds and in Vitro Degradation

Abstract

In this study, a polylactic acid (PLA)/tea polyphenols (TP) polymer blend was developed for coronary artery stents. Using a high-efficiency mixer, we prepared optimal mixtures, which were then hot- and cold-pressed into thin films of varying thicknesses. Scanning electron microscopy (SEM) and contact angle tests were used to analyze surface changes and biodegradability over time. The mechanical properties of drug-loaded films were evaluated via a universal testing machine. Tea polyphenols enhanced specimen hydrophilicity, biocompatibility, and stability by reinforcing the microstructure. This is crucial for long-term implants as it extends service life and minimizes complications from material fatigue.