The quadratic growth of attention computation and key-value (KV) cache with respect to sequence length is a central bottleneck for ultra-long-context language models and high-resolution generative models. We propose ProxyFormer, a general dual-stream architecture built upon proxy tokens. In each layer, fine-grained local features are compressed bottom-up into a small set of proxy states; expensive global interactions are performed only in the compressed proxy space; the globally contextualized proxies are then decompressed and injected top-down back into the local stream. Because the local stream persists across layers, fine-grained information that is not captured by one compression step remains accessible for later refinement, alleviating the irreversible information loss of conventional one-shot compression. We further introduce factorized multi-level compression/decompression, layer-wise dynamic compression ratios, asymmetric dual embeddings, and a proxy-only KV-cache inference scheme. On a 16GB GPU with batch size 1, a standard decoder-only model can train sequences of only about 20K tokens, whereas ProxyFormer with a compression ratio of 64 extends the trainable sequence length to about 0.7M. A model trained with a 64K window retains 92%-95% retrieval accuracy on a multi-needle retrieval task with 1,048,576 tokens, and a model trained with an 8K window exceeds 94% accuracy when extrapolated to 256K tokens. Preliminary image-generation experiments demonstrate the feasibility of ProxyFormer for both pixel-space and latent-space flow matching.
LifeSciBench is introduced, a benchmark of 750 expert-authored tasks designed to evaluate whether language models can handle realistic life science research work, with each constituent task paired with a human expert-written rubric.
Amelia Liu, Andrew Ho, Anne Marie Droste et al.· bioRxiv· 2 citations
A rapidly advancing precision-therapy pipeline-including antisense oligonucleotides to upregulate the intact allele, AAV-based gene replacement, CRISPR-mediated transcriptional activation, epigenetic modulators, and rational pathway-targeted small molecules-offers realistic prospects for disease modification.
Autistic children experience disproportionately high rates of anxiety, yet common interventions such as cognitive behavioural therapy and traditional mindfulness practices may be less effective due to their cognitive and abstract demands. Yoga nidra, a form of guided meditation using concrete visualisations and breath awareness, may offer a more accessible alternative. This mixed methods study evaluated the feasibility and pilot efficacy of a co-designed six-week online yoga nidra intervention targeting anxiety in autistic children aged 8-14 years. Neurophysiological and psychological data were collected from 13 participants using parent- and self-reported measures of anxiety (ASC-ASD), intolerance of uncertainty (IUSC), and emotion dysregulation (EDI), alongside heart rate variability (HRV). Notably, the cohort included a minimally speaking child, which demonstrates the potential for the intervention to extend to autistic children with language support needs, a group who are often underrepresented in similar research. Results indicated no statistically significant changes in anxiety over time; however, medium effect sizes were observed in self- (Hedge's g = 0.55) and parent-reported anxiety (Hedge's g = 0.45), with three participants moving from clinically significant to non-significant anxiety levels post-intervention. Additionally, intolerance of uncertainty and emotion dysregulation demonstrated small to medium effect size reductions (IUSC, Hedge's g = 0.50; EDI-Reactivity, Hedge's g = 0.55; EDI-Dysphoria, Hedge's g = 0.25), suggesting potential benefits of yoga nidra in these areas. Greater attendance was significantly associated with self-reported reductions in anxiety (ASC-ASD-SR, r = .757, p < .05), but not the other outcome measures. Unexpectedly, HRV outcomes indicated reduced autonomic functioning post-intervention. Additionally, qualitative data from semi-structured interviews with three child participants and their mothers from the study were analysed using reflexive thematic analysis, revealing five key themes of their experience: Thinking About the Body is Hard; We Want More; Homework Sucks; Making Mindfulness Concrete; and On-Screen and At Home is Convenient. While the online format was appreciated for its accessibility, challenges with adherence and scheduling highlighted the need for more flexible delivery models. This study advances upon prior research by being the first to develop a co-designed yoga nidra intervention specifically for autistic children. Findings support the feasibility of yoga nidra as a complementary intervention for autistic children and suggest directions for future research, including larger trials and further co-design with the autistic community.
Tundi Loftus, Shu H Yau, Sophia Soares et al.· Research in Developmental Di...· 1 citation
TestifAI, a deep learning testing framework for efficient and accurate estimation of robustness against combinations of perturbations, is proposed and partial model tomography is introduced, a novel approach to reconstructing model behaviour in a multi-perturbation space from tests that apply only a small number of perturbations.
Arooj Arif, T. Hartung, E. Botoeva et al.· 1 citation
A hybrid model, termed SE_LLM_ST, is introduced, which leverages recent advancements in large language models (LLMs) and transformer-based architectures to effectively capture both contextual and sequential information vital for Persian emotion recognition.
Toktam Khatibi, Elham Farahani· SN Computer Science· 0 citations
Large Language Models show potential in their diagnostic accuracy and consequent ability to reduce clinician burden, and may provide the greatest benefit when used to optimise referral quality at source, improving both clinician and potentially LLM triage downstream.
K. Surendran, I. Aziz, Glyndwr Jenkins· Current Surgery Reports· 0 citations
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
