CAR-T CELL THERAPY IN ONCOLOGY AND RHEUMATOLOGY

Abstract

Background: CAR-T cell therapy is a highly personalized form of treatment. it involves modifying T cells extracted from the patients white blood cells during cell collection. Genetic modification of said T cells allows for the extraction of chimeric antigen receptor (CAR), which are later multiplied and infused into the recipients organism. The use of such a highly personalized method yields promising results in both oncology and hematology where relapses and the severity of conditions require precise therapy. Aim: This narrative analysis aims to summarize and explore the present-day application of CAR-T cell therapy, currently held trials and possibilities for future therapy development in the fields of oncology and rheumatology. Material and methods: A search of relevant research databases was conducted to identify eligible papers. Results: CAR-T cell therapy shows promising results due to its mechanism of genetical modifications of patients’ own T-cells, thus allowing them to recognize surface antigens present on cancer cells and reduce symptoms and long-term consequences of autoimmune diseases. However, its use still is limited, and more research needs to undergo to better utilize CAR-T cell therapy. Conclusions: The use of CAR-T cell therapy in oncology and rheumatology is promising however, further studies are needed to assess its efficiency and safety.